Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009
Identifieur interne : 000033 ( France/Analysis ); précédent : 000032; suivant : 000034Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009
Auteurs : Isabel Pagani [Italie] ; Andrea Di Pietro [Italie] ; Alexandra Oteiza [France] ; Michela Ghitti [Italie] ; Nadir Mechti [France] ; Nadia Naffakh [France] ; Elisa Vicenzi [Italie]Source :
- mSphere [ 2379-5042 ] ; 2018.
English descriptors
- mix :
Abstract
We have uncovered that long-term circulation of seasonal influenza A viruses (IAV) in the human population resulted in the progressive acquisition of increased sensitivity to a component of the innate immune response: the type I interferon-inducible TRIM22 protein, which acts as a restriction factor by inducing the polyubiquitination of the IAV nucleoprotein (NP). We show that four arginine residues present in the NP of the 1918 H1N1 pandemic strain and early postpandemic strains were progressively substituted for by lysines between 1918 and 2009, rendering NP more susceptible to TRIM22-mediated ubiquitination. Our observations suggest that during long-term evolution of IAVs in humans, variants endowed with increased susceptibility to TRIM22 restriction emerge, highlighting the complexity of selection pressures acting on the NP.
Url:
DOI: 10.1128/mSphere.00110-18
PubMed: 29624498
PubMed Central: 5885024
Affiliations:
- France, Italie
- Languedoc-Roussillon, Lombardie, Occitanie (région administrative), Île-de-France
- Milan, Montpellier, Paris
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- to stream Main, to step Exploration: 000175
- to stream France, to step Extraction: 000033
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PMC:5885024Le document en format XML
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Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>San Raffaele Scientific Institute, Milan, Italy</addr-line></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author></analytic><series><title level="j">mSphere</title><idno type="eISSN">2379-5042</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>TRIM22</term><term>evolution</term><term>influenza A virus</term><term>nucleoprotein</term><term>restriction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We have uncovered that long-term circulation of seasonal influenza A viruses (IAV) in the human population resulted in the progressive acquisition of increased sensitivity to a component of the innate immune response: the type I interferon-inducible TRIM22 protein, which acts as a restriction factor by inducing the polyubiquitination of the IAV nucleoprotein (NP). We show that four arginine residues present in the NP of the 1918 H1N1 pandemic strain and early postpandemic strains were progressively substituted for by lysines between 1918 and 2009, rendering NP more susceptible to TRIM22-mediated ubiquitination. Our observations suggest that during long-term evolution of IAVs in humans, variants endowed with increased susceptibility to TRIM22 restriction emerge, highlighting the complexity of selection pressures acting on the NP.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Kash, Jc" uniqKey="Kash J">JC Kash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Capua, I" uniqKey="Capua I">I Capua</name></author><author><name sortKey="Kajaste Rudnitski, A" uniqKey="Kajaste Rudnitski A">A Kajaste-Rudnitski</name></author><author><name sortKey="Bertoli, E" uniqKey="Bertoli E">E Bertoli</name></author><author><name sortKey="Vicenzi, E" uniqKey="Vicenzi E">E Vicenzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sangster, My" uniqKey="Sangster M">MY 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Naffakh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eldin, P" uniqKey="Eldin P">P Eldin</name></author><author><name sortKey="Papon, L" uniqKey="Papon L">L Papon</name></author><author><name sortKey="Oteiza, A" uniqKey="Oteiza A">A Oteiza</name></author><author><name sortKey="Brocchi, E" uniqKey="Brocchi E">E Brocchi</name></author><author><name sortKey="Lawson, Tg" uniqKey="Lawson T">TG Lawson</name></author><author><name sortKey="Mechti, N" uniqKey="Mechti N">N Mechti</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Italie</li></country><region><li>Languedoc-Roussillon</li><li>Lombardie</li><li>Occitanie (région administrative)</li><li>Île-de-France</li></region><settlement><li>Milan</li><li>Montpellier</li><li>Paris</li></settlement></list><tree><country name="Italie"><region name="Lombardie"><name sortKey="Pagani, Isabel" sort="Pagani, Isabel" uniqKey="Pagani I" first="Isabel" last="Pagani">Isabel Pagani</name></region><name sortKey="Di Pietro, Andrea" sort="Di Pietro, Andrea" uniqKey="Di Pietro A" first="Andrea" last="Di Pietro">Andrea Di Pietro</name><name sortKey="Ghitti, Michela" sort="Ghitti, Michela" uniqKey="Ghitti M" first="Michela" last="Ghitti">Michela Ghitti</name><name sortKey="Vicenzi, Elisa" sort="Vicenzi, Elisa" uniqKey="Vicenzi E" first="Elisa" last="Vicenzi">Elisa Vicenzi</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Oteiza, Alexandra" sort="Oteiza, Alexandra" uniqKey="Oteiza A" first="Alexandra" last="Oteiza">Alexandra Oteiza</name></region><name sortKey="Mechti, Nadir" sort="Mechti, Nadir" uniqKey="Mechti N" first="Nadir" last="Mechti">Nadir Mechti</name><name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name><name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name><name sortKey="Naffakh, Nadia" sort="Naffakh, Nadia" uniqKey="Naffakh N" first="Nadia" last="Naffakh">Nadia Naffakh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|étape= Analysis
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|texte= Mutations Conferring Increased Sensitivity to Tripartite Motif 22 Restriction Accumulated Progressively in the Nucleoprotein of Seasonal Influenza A (H1N1) Viruses between 1918 and 2009
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